DEMOLITION work on the old Burnyeats building, located on Milford Waterfront, will begin on Monday, September 14.
The building will make way for the new 100-bed hotel which has been given approval by Pembrokeshire County Council.
Contractors will erect a temporary fence around the area which will soon become the construction site for the hotel.
A pedestrian diversion route has been created to allow people to move safely around the site.
Work is expected to last approximately 12 weeks.
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